The association between the IGF-1 index and low bone mass still existed (95% CI 0.02 (0.001–0.5), p=0.0209) even after adjusting for age, gender, CD duration, BMI, hypertension, dyslipidemia, diabetes, ALT, Scr, FT3, F24 pm, PTH, and osteocalcin (Table 3). The gene discussed is BGLAP; the disease is metabolic syndrome.