The association between the IGF-1 index and low bone mass still existed (95% CI 0.02 (0.001–0.5), p=0.0209) even after adjusting for age, gender, CD duration, BMI, hypertension, dyslipidemia, diabetes, ALT, Scr, FT3, F24 pm, PTH, and osteocalcin (Table 3). This evidence concerns the gene IGF1 and metabolic syndrome.