Skeletal PSMA uptake with corresponding CT substrate is not always associated withmalignancy, but has also been observed in benign disease such as fracture,degeneration, or hemangioma.13,19,20 In this report, lesions withcorresponding substrate were rated benign in 52% and in 30% of lesions withsubstrate the observers disagreed on the nature of lesions. The gene discussed is FOLH1; the disease is hemangioma.