HAVCR2 and neoplasm: Therefore, we next analyzed the tumor-infiltrating populations of CD4+ and CD8+ T cells for expression of the IRs lymphocyte activating protein 3 (LAG3), programmed cell death protein 1 (PD1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT), and T-cell immunoglobulin and mucin domain 3 (Tim3).