CD8A and neoplasm: However, given that a role for CD8+ T cells in suppressing MC38 tumor growth has been reported in C57Bl6 mice with fully murine p53 where a p53 mismatch is absent (40, 41), and that we have identified substantial frequencies of neoantigen-specific TILs in both P47 and S47 mice, it is unlikely that differences in a putative anti-murine p53 T-cell response between S47 and P47 mice are the primary driver of the differences in T-cell phenotypes between the p53 genotypes in this study.