The underlying basis for the impaired tumor suppressor function of P47S has been linked to increased production of glutathione and antioxidants (19, 20), impaired ability to regulate ferroptosis (6, 16), increased activation of mTOR (21), impaired ability to regulate replication error restart (22), and impaired ability to recognize and bind to double-strand breaks in DNA (23). Here, MTOR is linked to neoplasm.