This process promotes the activation of different pathways, which conduct the production of multiple inflammatory mediators (interleukins 6, 8, 1/β, 10, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor TNF-α, thromboxane A2, high mobility group box 1 protein (HMGB-1), thrombin and others) acting as effectors and triggering a systemic inflammatory response, sepsis, coagulopathy, tissue edema and hypoxia, finally cellular dysfunction and multiorgan failure [2]. The gene discussed is HMGB1; the disease is Sepsis.