HMGB1 and Sepsis: Cytokine production is the mainstay in developing sepsis and septic multiorgan failure in patients with secondary peritonitis; therefore, we proposed measurements in plasma and peritoneal fluid, at different moments in time, of interleukins (IL-6, IL-8, IL-10), and MCP-1, HMGB-1 concentrations, together with presepsin and procalcitonin in plasma, for determining their value in stratifying the risk of developing sepsis and septic multiorgan dysfunction in this category of patients.