To investigate the impact of asbestos on mesothelioma progression in mice that are genetically destined to develop mesothelioma, we used triple allelic mice previously described to be sufficient for mesothelioma development in the absence of fibre exposure: Cdkn2a nullizygous mice bearing homozygous floxed alleles of Nf2 and Trp53 (Cdkn2a−/−;Nf2fl/fl;Trp53 fl/fl–abbreviated as CNP) (Jongsma et al., 2008). The gene discussed is NF2; the disease is mesothelioma.