Genetic deletion of Trp53 (Marsella et al., 1997), Nf2 (Fleury-Feith et al., 2003), Cdkn2a (Altomare et al., 2011) and Bap1 (Kadariya et al., 2016) have each been shown to predispose mice to asbestos-induced mesothelioma, albeit with incomplete penetrance and variable latencies. This evidence concerns the gene CDKN2A and mesothelioma.