RNA-SEQ analysis of tumours harvested from end-point mice treated with or without AZD7507, confirmed the on-target effects of the drug on suppressing macrophages, with bulk tumour RNA showing reduced detection of transcripts for Csf1r itself along with numerous other Macrophage markers including Adgre, which encodes the F4/80 antigen, CD68, Mafb and Vsir, encoding Vista. This evidence concerns the gene VSIR and neoplasm.