A pilot study of chemotherapy treatment using previously published doses (Badhai et al., 2020), revealed CNP mice to be extremely sensitive to chemotherapy-induced toxicity, requiring reduction of both drugs to half the concentrations used in mesothelioma mouse model driven by triple deletion of Bap1, Cdkn2a and Nf2 (Badhai et al., 2020). Here, CDKN2A is linked to mesothelioma.