Firstly, our allele induction protocol did not give rise to off-target tumours, such as those reported using similar (Kukuyan et al., 2019; Badhai et al., 2020) or indeed identical (Jongsma et al., 2008) allelic mice induced with high-dose adenoviral-Cre vectors, which include sarcomas, lymphomas, and, in the case of Bap1 floxed mice, hepatocellular carcinomas. Here, BAP1 is linked to neoplasm.