One association that was missed in this analysis is dermal irritancy, although there was a weak association for activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the skin (see the DGRE results in the supplementary spreadsheet, “Tox21Enricher-Example Results and Chemical Lists”), suggestive of irritancy and hypersensitivity. Here, NFE2L2 is linked to Irritability.