This finding based on scRNA-seq analysis is consistent with the previous observations that IL-1β was expressed in IL-8high myeloid cells and that high IL-8 expression was associated with a reduced clinical benefit of PD-1 blockade therapy for metastatic urothelial carcinoma or renal cell carcinoma (41). The gene discussed is CXCL8; the disease is hereditary clear cell renal cell carcinoma.