For example, NF-κB and survival signals (R-HSA-209560); PKMTs methylate histone lysines (R-HSA-3214841); and Interleukin-1 processing (R-HSA-448706) were all highly activated in early stages of CLL disease (Figure 4D). The gene discussed is NFKB1; the disease is B-cell chronic lymphocytic leukemia.