VTN and cancer: Platelets contain various molecules that have been linked to cancer progression, including growth factors like platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-β), cytokines such as interleukin-1 beta (IL-1β) and interleukin-6 (IL-6), chemokines like CXCL12 (SDF-1), and extracellular matrix proteins like fibronectin and vitronectin (76–78).