As expected, all the AHD and mothers with a PD-1+ NK subset were seropositive for HCMV, a variable fraction of HCMV+ individuals (both ADH and mothers) were PD-1neg (23% in ADH versus 37% in mothers) and all the HCMV- individuals were negative for PD-1. This evidence concerns the gene AVP and mitochondrial DNA depletion syndrome 4a.