WNT2 and neoplasm: Excellent work was reported by Huang et al., who found that CAF-secreted WNT2 was involved in the differentiation and immunostimulatory activity of DCs in vitro, and accordingly, anti-WNT2 was observed to increase the level of intratumoral activated DCs and significantly improve the anti-tumor responses of DC-mediated antigen-specific CD8+ T cells in murine tumor models (109).