observed significant enrichment of Tregs and cDC2 in hypoxic regions of tumor samples from patients with HCC, as well as lower CD8+ T-cells, and found a significant downregulation of HLA-DR expression by cDC2 under hypoxic conditions, which may be related to the increased intercontact between Tregs and cDC2 during hypoxia (114). This evidence concerns the gene CD8A and neoplasm.