A number of other interactions, including the secretion of inhibitory cytokines such as IL-10 and TGF-β (72), delivery of miRNAs to DCs by secreted extracellular vesicles, thereby inducing a tolerogenic phenotype in DCs (73), expression of CD27 molecules that interfere with CD70/CD27 stimulatory signaling between DCs and effector T-cells (74), and direct induction of death through mutual contact with DCs (75), are also important means for Tregs to impede the onset of DCs-mediated tumor immunity. Here, TGFB1 is linked to neoplasm.