At present, the main mechanisms for chloasma treatment include the following: (1) inhibiting tyrosinase using topical preparations to reduce melanin synthesis; (2) increasing melanin transport through chemical stripping; (3) destroying melanin using a pigment-selective laser; (4) remodeling skin with laser; and (5) partially destructing epidermal melanocytes and dermal melanocytes using a dot matrix laser. This evidence concerns the gene TYR and freckles.