In fact, tumor-infiltrating lymphocytes (TILs), including CD4+ T regulatory cells (Tregs), can create an immunosuppressive environment by promoting immune tolerance to tumor cells (Bohling and Allison, 2008) and by eliminating members of the innate immune system like natural killer (NK) cells (Olkhanud et al., 2009). This evidence concerns the gene CD4 and neoplasm.