PTH and metabolic disease: Pseudohypoparathyroidism (PHP) was initially defined as a metabolic disorder characterized by resistance to parathyroid hormone (PTH), resulting in hypocalcemia and hyperphosphatemia, associated with specific features of Albright hereditary osteodystrophy, such as stocky build, brachydactyly, and short stature.1 Additional features, such as subcutaneous ossifications, early-onset obesity, and resistance to other hormones, were later described in PHP patients.