Besides CF, given its important regulatory rolein controllingcell differentiation, growth, and transformation, and its aberrantexpression, RNF5 can be considered an interesting drug target alsoin pathological conditions, such as tumorigenesis.41 Previous studies identified an upregulation of RNF5 inbreast cancer41 and tumor cell proliferationwere inhibited after silencing of RNF5. This evidence concerns the gene RNF5 and neoplasm.