The serum levels of FSH, LH, and TSH of patients before and after treatment for suprasellar germinoma was significantly lower than those of patients with non-suprasellar germinoma; median levels were 0.30 (IQR, 1.15) and 0.40 (IQR, 5.50) vs. 3.70 (IQR, 4.55) for FSH (p < .001); 0.95 (IQR, 0.88) and 1.00 (IQR, 0.60) vs. 2.35 (IQR, 1.10) for LH (p < .001); and 0.26 (IQR, 1.20) and 0.03 (IQR, 0.02) vs. 1.79 (IQR, 0.93) for TSH (p < .001). This evidence concerns the gene PLOD1 and germinoma.