IGF1R and adrenal gland neoplasm: In childhood especially, adrenocortical tumorigenesis has been linked to increased expression of NR5A1 (86, 87) and IGF2 (through aberrant regulation of the 11p H19/IGF2 imprinting locus) (88–90), and IGF1R blockade has been explored as a treatment for adrenal tumors in experimental models and trials (91–93).