To study cortex zonation in more detail, we used nephroblastoma overexpressed/cysteine-rich protein 61/connective tissue growth factor/nephroblastoma overexpressed gene-3 (NOV, also known as CCN3) as a marker for the DZ and sulfotransferase 2A1 (SULT2A1) as a marker for the FZ (35, 41, 42). The gene discussed is CCN2; the disease is Nephroblastoma.