TGFB1 and renal fibrosis: Consistent with this, Gerarduzzi et al. (151) demonstrated that silencing secreted modular calcium-binding protein 2 (SMOC2), which belongs to the SPARC family, attenuated renal fibrosis by inhibiting transforming growth factor-β (TGFβ)-mediated fibroblast-to-myofibroblast transition.