Based on proteins’ function and their potential relevance in viral infection, we selected 12 proteins (MAGED2, SMARCA4, STAT4, STAT6, ACTN2, CDCA7, DNMT3B, NOP2, RETSAT, SLC25A22, TELO2, and STAT2) for cleavage validation. The gene discussed is ACTN2; the disease is viral infectious disease.