SIRT3 and cancer: Indeed, SIRT3 in cancer exerts a context-dependentrole,13 being tumorigenic in some cancertypes, tumorsuppressor in others.14−16 One of the most studied oncogenic pathways concernsthe regulation of hypoxia-inducible factor-1α (HIF-1α),a key transcription factor activating several glycolytic genes involvedin the “Warburg effect”.