SIRT3 and cancer: In more detail, SIRT3 is predominantly located in the mitochondrialmatrix and has a major role in numerous mitochondrial metabolic processes,such as the tricarboxylic acid (TCA) cycle, the urea cycle, aminoacid metabolism, fatty acid oxidation, mitochondrial electron transportchain (ETC)/oxidative phosphorylation (OXPHOS), reactive oxygen species(ROS) detoxification, mitochondrial dynamics, and the mitochondrialunfolded protein response (UPR).10,11 In additionto its role in regulating metabolism-dependent diseases, SIRT3 displaysa double-sided function in cancer development.12