SIRT3 and benign thyroid gland neoplasm: First, older evidence showed that SIRT3 washighly expressed in DTC compared to benign thyroid tumors,23 while Wang et al. showed that MiR-1225-5p mighttrigger DTC cell proliferation and metastasis by targeting SIRT3.24 Newer findings by Yao and Wang, in a more clinicalsetting, indicate the opposite, showing that mRNA expression levelsof SIRT3 decreased in their DTC model compared to healthy cells andthat patients with high SIRT3 expression had a longer disease-freesurvival.25