ACHE and Constipation: Seizures were reportedside effects for lomustine with a p-value of 0.00199.Even though there are reports of known AChE inhibitors potentiallylinked to seizures the actual correlation is questionable.32 On the other hand, plecanatide, a medicationused for chronic idiopathic constipation (https://www.fda.gov/news-events/press-announcements/fda-approves-trulance-chronic-idiopathic-constipation), was found under the trade name Trulance to be linked to musclespasms with a p-value of 1.0E-7 in pAERS.