It is worth noting that GART is highly expressed in the intestinal lamina propria in Crohn's disease, and affects the rate of apoptosis during development of the disease.[87] Patients with Crohn's disease have an increased risk of CRC diagnosis and CRC mortality.[88] In the present study, the high expression level of GART in patients with CRC was first validated from GEO databases, and these were found to be significantly elevated in CRC samples compared with the healthy and adjacent tissues. The gene discussed is GART; the disease is Crohn disease.