It is known that the RUVBL1‐mediated Wnt/β‐catenin signaling axis has an important role in the occurrence and development of numerous types of malignancies.[53, 54] Our aim was to identify whether GART could mediate the RUVBL1/catenin signaling axis in the development of CRC. This evidence concerns the gene RUVBL1 and colorectal carcinoma.