Compared to stimulation of ATPase activity in RAD54-WT by RAD51, phosphomimic mutants in NTD (T2D and T3D) shows reduced ATPase activity and importantly RAD54-T3D exhibits significantly reduced ATPase activity (∼50% less) than the wild type protein (Figure 5E and F). The gene discussed is DNAH8; the disease is type 2 diabetes mellitus.