NME6 and cancer: Consistently, gene coessentiality network analysis across hundreds of heterogenous cancer cell lines using the FIREWORKS (Fitness Interaction Ranked nEtWORKS) web tool (Amici et al, 2021) revealed that the top coessential genetic interactors with NME6 are regulators of mtDNA replication, transcription, mitochondrial tRNA maturation and mitochondrial ribosome (mitoribosome) biogenesis, which is unique within the NME gene family (Fig EV4A).