The aging of the population is becoming more and more serious globally, the elderly tend to have a variety of chronic diseases such as diabetes, hypertension, and heart diseases, and have a higher chance of developing severe hepatitis E. It is worth noting that 35.8% of the anti-HEV IgM-positive study subjects are females of childbearing age in our study; infections in pregnant women usually have more severe consequences [2]. Here, CD40LG is linked to diabetes mellitus.