PSEN2 and melanoma: SLC45A2 is involved in melanosome maturation and pigmentation and associated with the risk of cutaneous malignant melanoma.32,33 The upregulation of PSEN2 increases human melanoma aggressiveness and worsens prognosis, and it is also the target of MYC.34 According to a previous study,35 TRPV2 exhibited ectopic distribution in both melanocytes and melanoma cells.