TP53 and thyroid gland carcinoma: It has been reported that melanin is partially attributed to the secretion of ɑ-melanocyte-stimulating hormone (ɑ-MSH) induced by keratinocytes, while the ultraviolet (UV)-induced secretion of ɑ-MSH in the skin is directly regulated by p53.30 Key signal molecule p53 is activated in response to DNA damage to promote the proliferation of melanoma and thyroid cancer cells.