It has been reported that melanin is partially attributed to the secretion of ɑ-melanocyte-stimulating hormone (ɑ-MSH) induced by keratinocytes, while the ultraviolet (UV)-induced secretion of ɑ-MSH in the skin is directly regulated by p53.30 Key signal molecule p53 is activated in response to DNA damage to promote the proliferation of melanoma and thyroid cancer cells. Here, TP53 is linked to melanoma.