18 The downregulation of βIVa-tubulins in lung cancer cells increases their sensitivity to tubulin-binding agents, such as vinorelbine, vincristine, and paclitaxel.19 Ross et al20 explored the impact of hypoxia on the proteome and found that TUBB4A differential expression is primarily involved in the structural and binding processes of prostate cancer. Here, TUBB4A is linked to lung cancer.