MicroRNA-214 suppresses TFAP2C to propel melanoma progression.43 The levels of TFAP2C methylation are evidently different between primary lesions and metastases of melanoma.44 Tubulin acetylation favors the recruitment of molecular chaperone Hsp90 to microtubules and the binding and signaling of kinase Akt/PKB and TF p53.45 Furthermore, Arai et al46 reported that tubulin inhibitor vinca alkaloid hijacks tumor suppressor p53 protein to enhance the expression of class II beta-tubulin isotype (mTUBB2) in mouse B16-F10 melanoma cells. This evidence concerns the gene AKT1 and melanoma.