AREG and psoriasis: Notably, K14-ARGE transgenic mice, which express human amphiregulin in the basal epidermis under human keratin 14-promoter [45], and K5.Stat3C mice, which harbor a constitutively activated form of Stat3 under the control of bovine K5 regulatory sequence [46], exhibit psoriasis-like skin phenotypes due to abnormal activation of keratinocytes.