FLT3 and acute myeloid leukemia: Moreover, compound 27 affords powerful antineoplastic activity versus FLT3-ITD acute myeloid leukemia cells, including MV4-16, and MOLM-18 with IC50s equal to 38.8 and 54.9 nM, respectively (Table 5), whereas no fundamental potency versus acute myeloid leukemia cells deficient of FLT3-ITD.