It was found that the cytotoxicity and cell death induced by compound 24 appeared as distinctive apoptotic morphology features, for example, cell shrinkage, nuclear condensation, and fragmentation with EC50 = 1.23 μMol/L; in addition to potent inhibition of both the FLT3-ITD anti-apoptotic factor RSK1 and AMPK in AML cells affording more circumvention of leukemia cells’ propagation. Here, FLT3 is linked to acute myeloid leukemia.