ENTPD1 and ischemia: In agreement with previous studies implicating extracellular ATP as the primary source for adenosine generation in ischemia of particular organs [4, 7–9], our studies targeting CD39 and CD73 demonstrate that ATP is also the likely source of extracellular adenosine following T/HS, a condition whose pathophysiology is much more complex than that of ischemia of the various organs.