This process involves various proteins (FoXO1/3A, NF-κB) and genes (MAFbx/Atrogin-1 and muscle RING-finger protein-1/MuRF1) regulated by the ubiquitin proteasome system (UPS) and autophagy-lysosome system (ALS) [12–14]. The gene discussed is FBXO32; the disease is amyotrophic lateral sclerosis.