Similarly, the mRNA expression of MuRF1 and Myostatin in the skeletal muscle of T2DM rats was significantly reduced in the DAPA + AE and DAPA + RT groups (P < 0.05, Fig. 4B, C), with a more substantial decrease occurring in the DAPA group (P < 0.01, Fig. 4B, C) when compared to the CON group. The gene discussed is MSTN; the disease is type 2 diabetes mellitus.