Also, primaquine can trigger life-threatening hemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD)-deficiency, [14] an X-linked enzymatic condition that is common in malaria-endemic settings, and in settings such as Thailand, is estimated to affect 13–17% of the population [15]. This evidence concerns the gene G6PD and hyperinsulinemic hypoglycemia, familial, 4.