Of the significant differentially expressed genes in the amyloid status-based primary analysis, the top five genes with highest direct association score were RPL17-C18orf32, HSP90AA1, MBP, SIRPB1, and GRINA. In a recent AD case–control study characterising hippocampal subfields, stereological data showed that the chaperone HSP90AA1 protein was downregulated in AD and associated with astrocytes, where the authors hypothesised that this is related to chaperone-mediated autophagy of amyloid and tau within AD [76]. The gene discussed is MAPT; the disease is Alzheimer disease.