ADAM10 and hepatocellular carcinoma: In the same way, another of the most critical genes, according to KPCA-IG, that seems to be prominent in the case of an HCC patient reflecting the same indication in the medical literature is ADAM10, known to be involved in the RIPing and shedding of numerous substrates leading to cancer progression and inflammatory disease [31], and indicated as a target for cancer therapy [13, 45], while being upregulated in metastasis cancers [20, 33].