ACSS2 and Alzheimer disease: To verify whether replenishing ACSS2 substrate (acetate) can achieve similar protection against AD, we performed an intragastric administration of glyceryl triacetate (GTA, an FDA-approved food additive, 2 g/kg/day) to the 8-month-old 5 × FAD mice or WT mice every day for 1 month, and analyzed their brains for AD-related pathology.