The stimulation of the onset and progression of CRC is often mediated by the Wnt/β-catenin pathway, and control of malignant phenotypes, including angiogenesis, proliferation, and invasion in a variety of cancers, including CRC, is the responsibility of the PI3K / AKT / mTOR pathway (Fig. 3b). This evidence concerns the gene MTOR and colorectal carcinoma.