It is noteworthy that this module contained the upregulated C1Q complex (Additional Table 3), which is the first component of the classical complement cascade and the prototypical innate anti-microbial defence mechanism, its functions including promotion of opsonisation/phagocytosis, lysis of bacteria/infected cells, augmentation of antibody responses [42], but also inhibition of Th2-associated airways eosinophilia [43] and IFN mediated signalling in pDC [44]. Here, IFNA1 is linked to Increased total eosinophil count.