Based on RNA sequencing of the PBMCs from HCC patients, we identified METTL7B, BCAM, CLDN18, DEFA1B, SOCS3, HBG2, GSTM1, RNASE3, ITGA9 and S100P as potential markers associated with poor prognosis, of which METTL7B, ITGA9, SOCS3 and RNASE3 were significantly upregulated in BCLC stage D patients. The gene discussed is HBG2; the disease is hepatocellular carcinoma.