The DEGs were translated using genecode V22 official annotation file, and the heatmap is shown in Fig. 1E. The top 10 upregulated genes in the HCC group, including METTL7B, BCAM, CLDN18, DEFA1B, SOCS3, HBG2, GSTM1, RNASE3, ITGA9 and S100P, were selected for follow-up study. This evidence concerns the gene SOCS3 and hepatocellular carcinoma.