However, limited inspiration could be achieved based on this part of analysis considering the fact that only few ccRCC samples were included in cBioPortal database, although various types of MMP9 (Figure S1A), IRF7 (Figure S1B), NFKB1 (Figure S1C) and HMOX1 (Figure S1D) genes alteration were observed in different human cancers indicating the potential different functions these genes play in human cancers. The gene discussed is MMP9; the disease is nonpapillary renal cell carcinoma.