Meanwhile, as for NFKB1 and HMOX1 genes which were indicated to relate with better patients prognosis, the expression tend to keep decreasing as the cancer stage and grade advancing, and their expression were lower in patients with lymph node metastasis, although the difference was not statistical significant presumably due to the limited patients cases number in N1 group (Fig. 5K-T). Here, HMOX1 is linked to metastatic malignant neoplasm in the lymph nodes.