HMOX1 and nonpapillary renal cell carcinoma: Therefore, the PPI network of the 269 genes was constructed followed by genes module analysis which highlighted a 46 genes containing cluster, and further survival analysis including GEPIA and UALCAN univariate survival as well as multivariate Cox Regression analysis of each of the 46 genes supported four genes: MMP9, NFKB1, IRF7 and HMOX1 to be associated with patients survival and worked as independent prognostic indicators in ccRCC development.