To further analyze survival relationship of the 46 selected immune related candidate genes, univariate survival analysis including UALCAN and GEPIA, as well as multivariate Cox regression analysis were in succession performed, and the results supported four genes, namely MMP9 (Fig. 3A), NFKB1 (Fig. 3B), IRF7 (Fig. 3C) and HMOX1 (Fig. 3D) as independent prognostic indicators in ccRCC, all four genes not only relate with patients overall survival but also progress free survival indicating their high potential in clinical medical use (Table 1). Here, MMP9 is linked to nonpapillary renal cell carcinoma.