MAPT and early-onset autosomal dominant Alzheimer disease: Deposits of fibrillar β‐amyloid peptide (Aβ) and intracellular bundles of self‐assembled hyperphosphorylated tau proteins (p‐tau) are two hallmark lesions of neurodegenerative diseases, such as Alzheimer's disease.[21] We also investigated the association between r‐DMV EVs and neurodegeneration by analyzing the expression of Aβ42 and Aβ40 in treated SY5Y cells.