BMP3, FLI1, IKZF1, NPTX2, SFRP1, SFRP2, SLC8A1 and VIM were combined into the HUNT-CRC diagnostic panel (HUNT-CRCd), considered positive if two or more of the eight markers were present (Supplementary Fig. 2A). Here, SFRP1 is linked to colorectal carcinoma.