TP53 and cancer: p53 plays a prominent role in tumor prevention.[1, 2] The tumor suppressive function of p53 is largely attributed to its ability to activate the expression of target genes that are involved in various cellular processes, such as cell cycle arrest, apoptosis, senescence, autophagy, ferroptosis, and cell metabolism.[3, 4, 5, 6, 7, 8] In approximately half of human cancers, p53 is inactivated by either chromosomal deletion or somatic mutation.