CD4 and neoplasm: Around the tumor center, the dense CD8+T cells, including a low number of the PD-1+Tim-3+IFN-γ+HLA-DR+ subtype, were adjacent to CD4+ T-cells of active Th1 and Th2 subtypes (S14), the rare Tregs and Bcl-6+ follicular T helper cells (Tfh).