Indeed, the dopaminergic system appears affected by statins administration, but while certain studies demonstrate the occurrence of concomitant dopaminergic and antidepressant- or anxiolytic-like effects [87], perhaps mediated by interaction with BDNF function [101, 102] or via potentiation of dopaminergic mechanisms [103] for simvastatin, others fail to show any concurrent changes in animal depressive or anxiety behaviour for atorvastatin [104]. Here, BDNF is linked to Anxiety.