Mechanistically, METTL3-YTHDF2 mediated m6A modification elevated LINC00839 levels; LINC00839 functions as a scaffold for c-Src phosphorylates β-catenin at Y654, promoting Wnt signaling activation; β-catenin inhibitor treatment sensitizes brain tumor to radiotherapy. The gene discussed is LINC00839; the disease is brain neoplasm.