Our study also confirmed that CTSC gene was not only upregulated and co-expressed with other potential asthma related genes in nasal epithelium of asthmatic subjects but also persistently upregulated in multiple tissue/cell types of asthmatic subjects, which reflects that upregulation of CTSC gene in multiple tissue/cell may have functional association with the development and progression asthma disease. This evidence concerns the gene CTSC and asthma.