ROC analysis revealed excellent performance of the identified 180 gene classifiers in discriminating the three BC molecular subtypes (AUC (HER2+) = 0.94, AUC (HR+) = 0.97, and AUC (TNBC) = 0.97) in an independent validation cohort from BRCA TCGA dataset (HR+ (n = 269), HER2+ (n = 11), and TNBC (n = 65)) as shown in Fig. 3D. Here, ERBB2 is linked to breast cancer.