CDK5 and cancer: The most extensive module was enriched for Pathways in Cancer, encompassing well-known cancer-related genes orthologous to humans, like Serine/threonine-protein kinase 1 (Pak1), Cell division control protein 42 homolog (Cdc42), or Cyclin-dependent kinase 5 (Cdk5) (Fig. 4a, Supplemental Tables 4 and 5—Module 11) [34–37].