KPTN and Cognitive impairment: The majority of individuals with KRD display consistent neurobehavioural traits, including intellectual impairment and features suggestive of autistic spectrum disorder (anxiety, stereotypies and repetitive speech) with variable hyperactivity and seizures.27-31 To investigate whether our mouse model recapitulates any of the neurobehavioural features of the human disorder, we evaluated Kptn KO mice with a series of functional tests.