LoF variants in TSCs are associated with tuberous sclerosis complex, a multi-system tissue overgrowth syndrome affecting brain, skin, kidney, heart and lung.82 We found that 36% of genes dysregulated in TSC2−/− neurons83 (Supplementary material, File 3C) are also differentially expressed in our KPTN−/− NPCs (301 of 834 expressed in NPCs, 1.35-fold over-enriched, hypergeometric test P = 4.3 × 10−10), thus identifying a common signal in neural cell types driven by convergent disease mechanisms affecting the mTOR pathway. This evidence concerns the gene MTOR and tuberous sclerosis.