CD40LG and infection: However, as with IgM antibodies, there were no significant differences in median levels between genders or comorbidities, except at the onset of infection (D00) when there was an increase in antibody levels in patients with comorbidities (0.98 (IQR 0.79–1.14) versus 0.83 (IQR 0.63–1.11), respectively (p = 0.003)) (Fig 5C).