IGF1 and neoplasm: The BM microenvironment (BMM) plays a central role in the pathogenesis of MM [4], where it can provide inflammatory agents as cytokines, growth factors like insulin-like growth factor-1 (IGF-1), and others, which support malignant cell growth, drug resistance and cytotoxicity of healthy cells [5]. Some of the prognostic factors related to the tumor burden are related to the signaling pathways and the associated transcription factors as STAT3 [6].