Many studies highlighted the importance of RGS in the autoimmune diseases as multiple sclerosis, Crohn’s disease, ulcerative colitis [17], and undifferentiated spondylo-arthritis, often associated with gastrointestinal lesions [18]. Also, RGS1 gene amplification was detected in various malignancies, including melanoma, non-Hodgkin lymphoma, retinoblastoma, pancreatic cancer, nasopharyngeal carcinoma [19], diffuse large B-cell lymphomas, follicular lymphomas, and multiple myeloma [11]. This evidence concerns the gene RGS1 and melanoma.