The expression of several constituents of the SWI/SNF complex, including Smarcc1, was recently demonstrated to be increased in patients suffering from Crohn’s disease when compared to the non-inflamed epithelium (35), suggesting that our findings on the role of SMARCA4 and SMARCC1 in controlling the maturation status of the intestinal epithelium might also extend to inflammatory conditions in the postnatal intestine. This evidence concerns the gene SMARCA4 and Crohn disease.